Small historical town located just 2 hours from Medellin. It was the capital of the region before the control of power was shifted to Medellin. If you’re interested in colonial architecture, white-washed walls, weathered churches (like The Catedral de Santa Fe de Antioquia, located in the main plaza) and old town squares then Santa Fe is a perfect day trip from Medellin.
http://www.medellincolombia.co/medellin-sightseeing/visit-nearby-towns/